Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC FTI-2153 (TFA) | 2820151-01-5 | 99.1% | 580.62 g/mol | C27H31F3N4O5S | 10MM 1ML
FTI-2153 TFA is the trifluoroacetic acid salt of a potent farnesyltransferase inhibitor supplied for research use. It is provided as a ready-to-use 10 mM solution in DMSO (1 mL) and in solid amounts, with supporting datasheet, SDS, and COA for characterization and safe handling.
Apexbio Technology LLC BIBP 3226 trifluoroacetate(Synonyms: BIBP3226 TFA, BIBP3226 trifluoroacetate salt, NPY Y1 receptor antagonist BIBP3226), 2mg, CAS: 1068148-47-9.
BIBP 3226 trifluoroacetate (CAS 1068148-47-9) is a non-peptide antagonist targeting neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptors showing binding affinity with Ki values of 1 1 nM (rNPY Y1) 79 nM (hNPFF2) and 108 nM (rNPFF) BIBP 3226 competes with NPFF prevents NPFF-induced inhibition of forskolin-stimulated cAMP production and blocks NPFF-dependent hypothermic and anti-opioid effects in rodent models This compound is employed experimentally to investigate NPY/NPFF system roles in anxiety analgesia and cardiovascular regulation
Medchemexpress LLC Mifamurtide (TFA) | 98.0% | 1351.52 | 1 MG
Mifamurtide TFA (MTP-PE TFA) is an analog of the muramyl dipeptide (MDP) that functions as a nonspecific immunomodulator by stimulating the immune response, activating macrophages and monocytes. It is a specific ligand for NOD2 and acts as an insulin sensitizer, with potential applications in rare disease and osteosarcoma research.
- Induces reduction of MG63 cell numbers when co-cultured with macrophages.
- Increases M1 polarization marker iNOS and M2 polarization marker CD206 mRNAs.
- Increases pro-inflammatory (IL-1β, IL-6) and anti-inflammatory (IL-4, IL-10) cytokines.
- Activates macrophages and monocytes, leading to upregulation of tumoricidal activity and secretion of pro-inflammatory cytokines.
- Shows a trend of diminished spontaneous lung metastasis dissemination in osteosarcoma models.
- Improves glucose tolerance during endotoxemia and in HFD-fed mice.
Medchemexpress LLC TP0628103 (TFA) | 2865106-78-9 | 99.6% | 1248.68 | 5 MG
TP0628103 (Compound 18) TFA is a selective inhibitor of MMP-7, with an IC50 value of 0.17 nM. MMP-7 plays an important role in cancer and fibrosis.
- Selective inhibitor of MMP-7
- IC50 value of 0.17 nM
- Plays an important role in cancer and fibrosis research
- For research use only
Medchemexpress LLC SAH-SOS1A TFA | 2896737-31-6 | 96.6% | 2301.55 | 1 MG
SAH-SOS1A TFA is a peptide-based SOS1/KRAS protein interaction inhibitor. It binds to wild-type and mutant KRAS with nanomolar affinity, directly and independently blocking nucleotide association. This compound impairs KRAS-driven cancer cell viability and exerts its effects by on-mechanism blockade of the ERK-MAPK phosphosignaling cascade downstream of KRAS.
- Peptide-based SOS1/KRAS protein interaction inhibitor
- Binds to wild-type and mutant KRAS (G12D, G12V, G12C, G12S, Q61H) with nanomolar affinity (EC50=106-175 nM)
- Directly and independently blocks nucleotide association
- Impairs cancer cell viability
- Blocks ERK-MAPK phosphosignaling cascade downstream of KRAS
Medchemexpress LLC Cys-TAT(47-57) TFA | 98.1% | 1661.99 | 10 MG
Cys-TAT(47-57) (Cys-[HIV-Tat (47-57)]) is an arginine rich cell penetrating peptide derived from the HIV-1 transactivating protein. This product is intended for research use only and is not sold to patients.
- Purity: 98.1%
- Molecular weight: 1661.99 (free base)
- Appearance: Solid
- Color: White to off-white
- Solubility in H2O: 100 mg/mL (ultrasonic needed)
- Solubility in DMSO: ≥ 100 mg/mL
Medchemexpress LLC GpTx-1 TFA | 99.6% | 4073.82 (free base) | 1 MG
GpTx-1 TFA is a peptide-based NaV1.7 sodium channel antagonist isolated from the venom of the Chilean spider Grammostola porter. It demonstrates potent inhibitory activity against the NaV1.7 channel with an IC50 value of 10 nM. It also exhibits excellent selectivity for NaV1.4 (IC50 = 0.301 μM) and NaV1.5 (IC50 = 4.20 μM), demonstrating >20-fold and >950-fold selectivity, respectively. This product is for research use only.
- Potent inhibitory activity against NaV1.7 channel with an IC50 value of 10 nM.
- Exhibits >20-fold selectivity for NaV1.4 (IC50 = 0.301 μM).
- Exhibits >950-fold selectivity for NaV1.5 (IC50 = 4.20 μM).
- Isolated from the venom of the Chilean spider Grammostola porter.
Medchemexpress LLC MPSD control peptide (TFA) | 99.8% | 3080.76 (free base) | 1 MG
MPSD TFA (MARCKS-ED TFA) is the TFA salt form of MPSD, a 25-amino acid peptide derived from the myristoylated alanine-rich C-kinase substrate (MARCKS). It functions as a biological probe capable of sensing membrane curvature and recognizing phosphatidylserine, making it useful for studying membrane shape and lipid composition.
- Derived from MARCKS effector domain sequence
- Senses membrane curvature
- Recognizes phosphatidylserine
- Useful for studying membrane shape and lipid composition
- Appears as a white to off-white solid
- High purity (99.8%)
- Molecular weight: 3080.76 (free base)
Medchemexpress LLC Cys-PKHB1 TFA | 65.8% | 1487.88 | 1 MG
Cys-PKHB1 (Cys-txCD47) TFA is a peptide conjugated to PKHB1, which is a CD47 agonist peptide and a thrombospondin-1 peptide mimic with antitumor effects. This peptide induces mitochondrial alterations, ROS generation, intracellular Ca+ accumulation, and calcium-dependent cell death in breast cancer cells. It also induces immune system activation in breast cancer cells through immunogenic cell death.
- Peptide conjugated to PKHB1
- Acts as a CD47 agonist
- Functions as a thrombospondin-1 peptide mimic
- Induces mitochondrial alterations
- Promotes ROS generation
- Leads to intracellular Ca+ accumulation
- Causes calcium-dependent cell death in breast cancer cells
- Induces immune system activation in breast cancer cells
Medchemexpress LLC Gplgiagq tfa | 99.9% | 825.83 | 50 MG
GPLGIAGQ TFA is an MMP2-cleavable polypeptide used as a stimulus-sensitive linker in liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. It can also be utilized to synthesize unique MMP2-targeted photosensitizers in photodynamic therapy (PDT). This product is for research use only.
- Used as a stimulus-sensitive linker in liposomal and micellar nanocarriers for tumor targeting
- Can be utilized to synthesize unique MMP2-targeted photosensitizers in photodynamic therapy (PDT)
- For research use only
- MMP2-cleavable polypeptide
- Target: MMP2
- Molecular weight: 825.83
- Formula: C33H54F3N9O12
- Appearance: solid, white to off-white
- Sequence: Gly-Pro-Leu-Gly-Ile-Ala-Gly-Gln
Medchemexpress LLC D-GsMTx4 TFA | 99.89% | 4095.84 | 2 MG
D-GsMTx4 TFA is a spider peptide and the D enantiomer of GsMTx4. It inhibits the mechanosensitive ion channel Piezo2, [Ca2+]i elevation, and mTOR and PI3K-Akt signaling pathways. This peptide can be used in research related to mechanical stress, chronic pain, and idiopathic pulmonary fibrosis.
- Inhibits Piezo2-mediated mechanosensitive inward currents
- Decreases phosphorylation levels in mTOR and PI3K-Akt signaling pathways
- Inhibits mechanical stimulation-evoked [Ca2+]i increases
- Significantly inhibits mechanical allodynia and thermal hyperalgesia
Medchemexpress LLC Z-VRPR-FMK TFA | 1926163-57-6 | MFCD18782585 | 95.9% | 790.81 | 100 UG
Z-VRPR-FMK (TFA) (VRPR), a tetrapeptide, is a selective and irreversible MALT1 (Mucosa-associated lymphoid tissue lymphoma translocation protein 1) inhibitor. It can protect against influenza A virus (IAV) infection.
- Selective and irreversible MALT1 inhibitor
- Tetrapeptide
- Protects against influenza A virus (IAV) infection