Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Pf15 TFA | 99.7% | 969.97 | C46H50F3N13O8 | 5 MG
A heterobifunctional PROTAC that recruits cereblon to promote degradation of FLT3-ITD. It reduces FLT3 and STAT5 phosphorylation, inhibits proliferation of FLT3-ITD-positive cells, and shows tumor growth inhibition in preclinical models. Supplied as a trifluoroacetic acid salt for laboratory research.
Medchemexpress LLC Ceftolozane trifluoroacetate salt | 1628046-32-1 | 98.2% | 780.71 g/mol | C25H31F3N12O10S2 | 25 MG
Ceftolozane TFA is the trifluoroacetate salt of ceftolozane, a cephalosporin-class antibiotic active against Gram-negative bacteria. It is provided for research use in antibacterial studies, assay development, and medicinal chemistry where it can serve as a synthetic intermediate for the design and optimization of novel antibiotic candidates.
- Trifluoroacetate salt form for improved stability and handling.
- Active against Gram-negative bacteria.
- Suitable for medicinal chemistry and synthetic applications.
- Available in small research quantities for assay development.
- Characterized with confirmed purity and molecular weight.
Medchemexpress LLC L-lysine, L-lysyl-L-glutaminyl-L-phenylalanyl- | 99.6% | 891.73 | 5 MG
KQFK TFA is an inactive control peptide, supplied as the TFA salt form. This compound, with a molecular formula of C32H46F9N7O12 and a molecular weight of 891.73, presents as a white to off-white solid with a purity of 99.6%. It is intended for research use only.
- Inactive control peptide, TFA salt form
- White to off-white solid appearance
- High purity of 99.6%
- Powder can be stored for 2 years at -80°C or 1 year at -20°C in sealed conditions, away from moisture
- In solvent, stable for 6 months at -80°C or 1 month at -20°C with sealed storage, away from moisture
Medchemexpress LLC LLVK TFA | 585.66 | 25 MG
LLVK TFA is a selective IκB phosphorylation inhibitor. It reduces LPS-induced pro-inflammatory cytokines (IL-1β, IL-6, TNF-α). LLVK TFA is promising for research of inflammatory bowel disease and rheumatoid arthritis.
- Selective IκB phosphorylation inhibitor
- Reduces LPS-induced pro-inflammatory cytokines (IL-1β, IL-6, TNF-α)
- Promising for research of inflammatory bowel disease
- Promising for research of rheumatoid arthritis
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic acid Reage
TRIFLUOROACETIC Trifluoroacetic acid Reage
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic acid | 76-05-1 | MFCD00004169 | 10 x 1 mL
Trifluoroacetic acid | Purity: 99% | Mol Wt: 114.02 | 76-05-1 | MFCD00004169 | 10 x 1 mL
Medchemexpress LLC Llvk tfa | 585.66 | 5 MG
LLVK TFA is a selective IκB phosphorylation inhibitor. It reduces LPS-induced pro-inflammatory cytokines (IL-1β, IL-6, TNF-α), making it promising for research of inflammatory bowel disease and rheumatoid arthritis.
- Selective IκB phosphorylation inhibitor
- Reduces LPS-induced pro-inflammatory cytokines (IL-1β, IL-6, TNF-α)
- Promising for research of inflammatory bowel disease
- Promising for research of rheumatoid arthritis
Medchemexpress LLC BIBP3226 TFA | 1068148-47-9 | 99.3% | 587.59 | 5 MG
BIBP3226 TFA is a potent and selective neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist, with Ki values of 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF, respectively. It has been observed to display an anxiogenic-like effect.
- Potent and selective neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist.
- Ki values of 1.1 nM for rNPY Y1, 79 nM for hNPFF2, and 108 nM for rNPFF.
- Induces an anxiogenic-like effect at higher doses in vivo.
- Available in 5 mg quantity.
Medchemexpress LLC NLS-StAx-h TFA | 98.9% | 3559.28 | 1 MG
NLS-StAx-h TFA is a selective, cell permeable, stapled peptide that inhibits Wnt signaling, with an IC50 of 1.4 μM. It effectively inhibits interactions between β-catenin and transcription factors and demonstrates anti-proliferative effects on cancer cells, including SW-480 and DLD-1 colorectal cancer cells.
- Selective, cell permeable, stapled peptide
- Inhibits Wnt signaling with an IC50 of 1.4 μM
- Efficiently inhibits β-catenin-transcription factor interactions
- Shows anti-proliferation of cancer cells
- Inhibits proliferation of colorectal cancer cells (SW-480 and DLD-1 cells) by more than 80% at 10 μM
- Inhibits migration of DLD-1 colorectal cancer cells in a dose-dependent manner
Medchemexpress LLC Astressin 2B TFA | 98.5% | 4041.69 | 1 MG
Astressin 2B TFA is a blood-brain barrier-impermeable, highly selective CRFR2 antagonist. It blocks protective effects mediated by CRFR2, exacerbating indomethacin-induced hemorrhagic intestinal injury in rats. This compound reverses the protective effects of Urocortin 1 against intestinal hypermotility, bacterial invasion, and upregulation of inflammatory mediators. It is an important tool molecule for investigating intestinal protective mechanisms of CRFR2.
- Highly selective CRFR2 antagonist
- Blocks anxiogenic effect of Urocortin 2
- Attenuates stress-induced anxiety-related behaviors
- Exacerbates intestinal epithelial damage in specific models
- Important tool for investigating intestinal protective mechanisms of CRFR2
Medchemexpress LLC Astax-35r TFA | 99.1% | 2392.86 | 5 MG
aStAx-35R TFA is a stapled peptide that antagonizes the nuclear form of β-catenin and inhibits Wnt signaling. It competitively inhibits the binding of β-catenin to TCF4 and selectively induces growth inhibition of Wnt-dependent cancer cells.
- Antagonizes nuclear form of β-catenin.
- Inhibits Wnt signaling.
- Competitively inhibits the binding of β-catenin to TCF4.
- Selectively induces growth inhibition of Wnt-dependent cancer cells.
Medchemexpress LLC GpTx-1 TFA | 1661050-12-9 | 99.6% | 4073.82 | 100 UG
GpTx-1 TFA is a peptide-based NaV1.7 sodium channel antagonist isolated from the venom of the Chilean spider Grammostola porter. It demonstrates potent inhibitory activity against the NaV1.7 channel with an IC50 value of 10 nM. This compound also exhibits excellent selectivity for NaV1.4 (IC50 = 0.301 μM) and NaV1.5 (IC50 = 4.20 μM).
- Potent inhibitory activity against NaV1.7 channel with an IC50 value of 10 nM.
- Selective for NaV1.4 (IC50 = 0.301 μM).
- Selective for NaV1.5 (IC50 = 4.20 μM).
- IC50 for NaV1.3 is 0.0203 μM.
- IC50 for NaV1.8 is 12.2 μM.
Medchemexpress LLC Cef20 (Tfa) | 99.3% | 1057.19 | 25 MG
CEF20 TFA is an HLA-A*0201-restricted epitope from cytomegalovirus pp65 (495-503).
- High purity of 99.31%
- Molecular weight of 1057.19
- Solid appearance
- White to off-white color
- Sequence: Asn-Leu-Val-Pro-Met-Val-Ala-Thr-Val (NLVPMVATV)
- Soluble in DMSO
- Store in sealed container, away from moisture
- Powder storage: -80°C for 2 years, -20°C for 1 year
- Storage in solvent: -80°C for 6 months, -20°C for 1 month
Apexbio Technology LLC SCH772984 TFA 942183-80-4 (free base) 5mg
SCH772984 TFA is a small-molecule inhibitor targeting extracellular signal-regulated kinase 1/2 (ERK1/2) It is designed to inhibit ERK catalytic activity thereby blocking phosphorylation of downstream substrates and regulating the RAS-RAF-MEK-ERK signaling pathway SCH772984 TFA exerts its biological activity primarily through direct interaction with ERK1/2 acting as an ATP-competitive inhibitor Based on these pharmacological properties SCH772984 TFA holds research potential in studies examining ERK signaling s role in oncogenic pathway activation tumor cell growth survival mechanisms and resistance phenomena in various cancer models
Medchemexpress LLC TcY-NH2 TFA ((trans-cinnamoyl)-YPGKF-NH2 TFA) | 1262750-73-1 | 99.7% | 853.88 | 10 MG
tcY-NH2 TFA is a potent and selective PAR4 antagonist peptide. It is capable of inhibiting thrombin- and AY-NH2-induced platelet aggregation and endostatin release. This peptide is suitable for research applications in inflammation and immunology.
- Potent and selective PAR4 antagonist peptide.
- Inhibits thrombin- and AY-NH2-induced platelet aggregation.
- Prevents endostatin release.
- Suitable for inflammation and immunology research.
- Purity of 99.7%.
- Soluble in DMSO at 100 mg/mL.
- Demonstrated activity in various in vitro and in vivo models.